ENTEROCYTES ON RAT JEJUNAL VILLI BUT NOT IN THE CRYPTS POSSESS M3 MESSENGERRNA FOR THE M3-MUSCARINIC-RECEPTOR LOCALIZED BY INSITU HYBRIDIZATION

被引：12

作者：

PRZYBORSKI, SA ^{[1
]}

LEVIN, RJ ^{[1
]}

机构：

[1] UNIV SHEFFIELD,DEPT BIOMED SCI,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

来源：

EXPERIMENTAL PHYSIOLOGY | 1993年 / 78卷 / 01期

关键词：

D O I：

10.1113/expphysiol.1993.sp003666

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Localization of m3 mRNA, for the expression of the M3 muscarinic receptor, along the crypt-villus axis, was undertaken in rat jejunum by in situ hybridization. While enterocytes on the lower two-thirds of the villi showed the presence of m3 mRNA it was absent in the crypt enterocytes. This indicates that the final locus of muscarinically activated jejunal secretion is mediated by the M3 receptor on the enterocytes of the villi and not via the crypt cells.

引用

页码：109 / 112

页数：4

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