THE C-ELEGANS UNC-18 GENE ENCODES A PROTEIN EXPRESSED IN MOTOR-NEURONS

被引：96

作者：

GENGYOANDO, K

KAMIYA, Y

YAMAKAWA, A

KODAIRA, K

NISHIWAKI, K

MIWA, J

HORI, I

HOSONO, R

机构：

[1] KANAZAWA UNIV,SCH MED,DEPT BIOCHEM,KANAZAWA,ISHIKAWA 920,JAPAN

[2] KANAZAWA MED UNIV,DEPT BIOCHEM,UCHINADA,ISHIKAWA,JAPAN

[3] KANAZAWA MED UNIV,DEPT BIOL,UCHINADA,ISHIKAWA,JAPAN

[4] TOYAMA UNIV,DEPT TECHNOL,TOYAMA 930,JAPAN

[5] NEC CORP LTD,FUNDAMENTAL RES LABS,TSUKUBA,JAPAN

来源：

NEURON | 1993年 / 11卷 / 04期

关键词：

D O I：

10.1016/0896-6273(93)90080-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The C. elegans unc-18 gene is required to maintain normal acetylcholine levels. We determined the complete structure of an unc-18 cDNA that encodes a protein of 591 highly charged and hydrophilic amino acids. The protein shows sequence similarity with elements of the secretory pathway in the yeast S. cerevisiae. Antibodies raised against a portion of the unc-18-encoded protein (UNC-18) detected a 68 kd soluble antigen on immunoblots and intensely stained all ventral cord motor neurons in situ. These findings suggest that UNC-18 participates in the axonal transport system and influences the acetylcholine flow in motor neurons.

引用

页码：703 / 711

页数：9

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