REDUCED PROCONVULSANT ACTIVITY OF CAFFEINE IN RATS AFTER A SERIES OF ELECTROCONVULSIVE SEIZURES

被引:6
作者
FRANCIS, A
FOCHTMANN, L
机构
[1] Department of Psychiatry Health Sciences Center T-10, SUNY Stony Brook, Stony Brook, 11794, NY
关键词
ELECTROCONVULSIVE SHOCK; SEIZURES; ADENOSINE ANTAGONISTS; CAFFEINE; RATS; 1-ALLYL-3,7-DIMETHYL-8-P-SULFOXANTHINE; 8-CYLCOPENTYL-1,3-DIPROPYLAXANTHINE;
D O I
10.1007/BF02246060
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A variety of neurotransmitter receptor changes occur after a course of electroconvulsive seizures (ECS) in rats, including an increased density of adenosine A(1) sites. Adenosine antagonism has been related to the proconvulsant action of methylxanthines such as caffeine. We determined tonic-clonic seizure duration in rats given ECS with caffeine (0-175 mg/kg, IP) after a course of one or six daily ECS. A single day of ECS did not affect the dose-dependent proconvulsant action of caffeine. After six daily ECS, the proconvulsant action of caffeine was reduced. After nine daily ECS, an A(1) antagonist (8-cyclopentyl-1,3-dipropylxanthine) and an A(2A) antagonist (1-allyl-3,7-dimethyl-8-p-sulfophenylxanthine) showed reduced proconvulsant activity. The results suggest that the reduced proconvulsant action of caffeine after chronic ECS depends on adenosine antagonism.
引用
收藏
页码:99 / 104
页数:6
相关论文
共 49 条
[1]   CAFFEINE MODIFICATION OF KINDLED AMYGDALOID SEIZURES [J].
ALBERTSON, TE ;
JOY, RM ;
STARK, LG .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1983, 19 (02) :339-343
[2]   ALTERATIONS OF A1 ADENOSINE RECEPTORS IN DIFFERENT MOUSE-BRAIN AREAS AFTER PENTYLENTETRAZOL-INDUCED SEIZURES, BUT NOT IN THE EPILEPTIC MUTANT MOUSE TOTTERING [J].
ANGELATOU, F ;
PAGONOPOULOU, O ;
KOSTOPOULOS, G .
BRAIN RESEARCH, 1990, 534 (1-2) :251-256
[3]   PENETRATION OF ADENOSINE ANTAGONISTS INTO MOUSE-BRAIN AS DETERMINED BY EXVIVO BINDING [J].
BAUMGOLD, J ;
NIKODIJEVIC, O ;
JACOBSON, KA .
BIOCHEMICAL PHARMACOLOGY, 1992, 43 (04) :889-894
[4]   CLINICAL-PHARMACOLOGY OF CAFFEINE [J].
BENOWITZ, NL .
ANNUAL REVIEW OF MEDICINE, 1990, 41 :277-288
[5]   CHRONIC CAFFEINE CONSUMPTION INCREASES THE NUMBER OF BRAIN ADENOSINE RECEPTORS [J].
BOULENGER, JP ;
PATEL, J ;
POST, RM ;
PARMA, AM ;
MARANGOS, PJ .
LIFE SCIENCES, 1983, 32 (10) :1135-1142
[6]   BINDING OF THE A1-SELECTIVE ADENOSINE ANTAGONIST 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE TO RAT-BRAIN MEMBRANES [J].
BRUNS, RF ;
FERGUS, JH ;
BADGER, EW ;
BRISTOL, JA ;
SANTAY, LA ;
HARTMAN, JD ;
HAYS, SJ ;
HUANG, CC .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1987, 335 (01) :59-63
[7]  
CALEV A, 1993, CONVULSIVE THER, V9, P95
[9]   FUNCTIONAL COUPLING OF HUMAN ADENOSINE RECEPTORS TO A LIGAND-DEPENDENT REPORTER GENE SYSTEM [J].
CASTANON, MJ ;
SPEVAK, W .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 198 (02) :626-631
[10]  
CHIN J, 1988, ANN NEUROL, V26, P69