STY, A TYROSINE-PHOSPHORYLATING ENZYME WITH SEQUENCE HOMOLOGY TO SERINE THREONINE KINASES

被引：128

作者：

HOWELL, BW

AFAR, DEH

LEW, J

DOUVILLE, EMJ

ICELY, PLE

GRAY, DA

BELL, JC

机构：

[1] UNIV OTTAWA,DEPT BIOCHEM,451 SMYTH RD,OTTAWA K1H 8M5,ONTARIO,CANADA

[2] UNIV OTTAWA,DEPT MED,OTTAWA K1H 8M5,ONTARIO,CANADA

[3] MCGILL UNIV,DEPT BIOCHEM,MONTREAL H3G 1Y6,QUEBEC,CANADA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 01期

关键词：

D O I：

10.1128/MCB.11.1.568

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have cloned a novel kinase (STY) from an embryonal carcinoma cell line. Sequence analysis of the STY cDNA reveals that it shares sequence homology with serine/threonine-type kinases and yet the bacterial expression product of the STY cDNA appears to have serine-, threonine-, and tyrosine-phosphorylating activities. The predicted STY protein is highly basic and contains a putative nuclear localization signal. During differentiation, two new mRNAs were detected in addition to the embryonic transcript.

引用

页码：568 / 572

页数：5

共 39 条

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