SITE-SPECIFIC INCORPORATION OF NONNATURAL RESIDUES INTO PEPTIDES - EFFECT OF RESIDUE STRUCTURE ON SUPPRESSION AND TRANSLATION EFFICIENCIES

被引：63

作者：

BAIN, JD ^{[1
]}

WACKER, DA ^{[1
]}

KUO, EE ^{[1
]}

CHAMBERLIN, AR ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT CHEM,IRVINE,CA 92717

来源：

TETRAHEDRON | 1991年 / 47卷 / 14-15期

关键词：

D O I：

10.1016/S0040-4020(01)81776-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A systematic survey of the structural requirements for biosynthetic incorporation of non-natural residues into a polypeptide is presented. Relative translation efficiencies for a series of 12 semi-synthetic acylated suppressor tRNAs ranged from 0 to 91% depending on the structure of the residue incorporated.

引用

页码：2389 / 2400

页数：12

共 36 条

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