CORTICOTROPIN RELEASING HORMONE, INTERLEUKIN-1-ALPHA, AND TUMOR-NECROSIS-FACTOR-ALPHA SHARE CHARACTERISTICS OF STRESS MEDIATORS

被引：36

作者：

BIANCHI, M ^{[1
]}

SACERDOTE, P ^{[1
]}

LOCATELLI, L ^{[1
]}

MANTEGAZZA, P ^{[1
]}

PANERAI, AE ^{[1
]}

机构：

[1] UNIV MILAN,DEPT PHARMACOL,VIA VANVITELLI 32,I-20129 MILAN,ITALY

来源：

BRAIN RESEARCH | 1991年 / 546卷 / 01期

关键词：

CORTICOTROPIN RELEASING HORMONE; INTERLEUKIN-1; TUMOR NECROSIS FACTOR; STRESS; NALOXONE; ANALGESIA;

D O I：

10.1016/0006-8993(91)91168-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin-1-alpha and tumor necrosis factor-alpha induce in increase in pain thresholds in the rat. We now show that also the corticotropin releasing hormone induces an analgesic effect that, similarly to what is observed with the two cytokines, is not reversible by naloxone. Moreover, we also show that after the administration of interleukin-1-alpha, tumor necrosis factor-alpha, and corticotropin releasing hormone, naloxone becomes analgesic itself. A similar observation was also made in the human and the experimental animal after exposure to stressful conditions. The results obtained suggest that the two cytokines share with corticotropin releasing hormone some characteristics of stress mediators.

引用

页码：139 / 142

页数：4

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