COMPARISON OF THE LECTIN-LIKE ACTIVITY OF PERTUSSIS TOXIN WITH 2 PLANT-LECTINS THAT HAVE DIFFERENTIAL SPECIFICITIES FOR ALPHA-(2-6) AND ALPHA-(2-3)-LINKED SIALIC-ACID

被引：18

作者：

HEERZE, LD

ARMSTRONG, GD

机构：

[1] Department of Medical Microbiology and Infectious Diseases, University of Alberta, Edmonton

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(90)91579-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this report we have compared the lectin-like properties of Pertussis toxin with two plant lectins which are known to possess different specificities towards terminal Neu5Ac Gal linkages on glycoconjugates. The hemagglutinin from elderberry bark (Sambucus nigra) has a binding specificity for terminal Neu5Ac α(2-6) Gal sequences and was found to bind a series of glycoconjugates with a similar specificity as Pertussis toxin. The binding specificity of Pertussis toxin was different from that of the leukoagglutinin from the seeds of Maackia amurensis which preferentially binds terminal Neu5Ac α(2-3) Gal sequences. These observations confirm the specificity of Pertussis toxin for Neu5Ac α(2-6) Gal glycoconjugate sequences. © 1990.

引用

页码：1224 / 1229

页数：6

共 20 条

[1] MAINTENANCE OF BIOLOGICAL-ACTIVITY OF PERTUSSIS TOXIN RADIOIODINATED WHILE BOUND TO FETUIN-AGAROSE [J].