EFFECT OF FIBRINOGEN DEGRADATION PRODUCTS AND SOME LYSINE ANALOGS ON THE DISSOCIATION OF PLASMIN(OGEN)-FIBRIN COMPLEXES

被引：24

作者：

CEDERHOLMWILLIAMS, SA

SWAIN, A

机构：

[1] Department of Haematology, John Radcliffe Hospital, Oxford

来源：

THROMBOSIS RESEARCH | 1979年 / 16卷 / 5-6期

关键词：

6-AHA; complexes; dissociation; fibrin; fragment-E; Plasmin(ogen);

D O I：

10.1016/0049-3848(79)90214-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibrin carries sites which bind plasmin and preactivated plasminogen (mol.wt. 84,000) allowing the formation of stable complexes. Fibrinogen degradation product E interferes with this complex formation suggesting that the plasmin(ogen) binding site is present in this fragment. The complexes are also dissociated by the anti-fibrinolytic agents 6-aminohexanoic acid and aminomethyl cyclohexanoic acid which both compete for the fibrin binding site of plasmin and plasminogen. © 1979.

引用

页码：705 / 713

页数：9

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