HOW LONG SHOULD CATHETER-ACQUIRED URINARY-TRACT INFECTION IN WOMEN BE TREATED - A RANDOMIZED CONTROLLED-STUDY

Objective: To determine the optimal management of catheter-acquired bacteriuria after short-term catheter use in women. Patients: Asymptomatic patients (119) with catheter-acquired bacteriuria were randomly assigned to receive no therapy, a single dose (320-1600 mg) of therapy with trimethoprim-sulfamethoxazole, or 10 days (160-800 mg twice daily) of therapy. Thirty-two patients with lower tract symptoms alone received a single dose or 10 days of therapy, and 10 patients with upper tract symptoms or signs received 10 days of therapy. Main Results: The mean and median durations of catheter use were 6 and 4 days, respectively. Bacteriuria resolved within 14 days without therapy in 15 of 42 (36%; 95% CI, 21% to 51%) asymptomatic patients. Seven of the remaining patients developed symptoms. Single-dose therapy resolved infection in 30 of 37 patients (81%; CI, 68% to 94%); 10 days of therapy resolved infection in 26 of 33 (79%; CI, 65% to 93%). For patients with lower tract symptoms alone, resolution rates with single-dose therapy or 10 days of therapy were similar (11 of 14 [79%] and 13 of 16 [81%], respectively). Ten days of therapy resolved infection in 6 of 9 (67%) patients with upper tract symptoms. Infection was resolved more often in women who were less-than-or-equal-to 65 years than in older women (62 of 70 [89%] versus 24 of 39 [62%]; P < 0.001). Bacteriuria resolved spontaneously more frequently in younger (14 of 19 [74%] compared with 1 of 23 older women [4%]; P < 0.001). Single-dose therapy resolved infection in 31 of 33 (94%) patients who were less-than-or-equal-to 65 years. Conclusions: Asymptomatic bacteriuria after short-term catheter use frequently becomes symptomatic and should be treated. For asymptomatic patients and patients with lower tract symptoms alone, single-dose therapy was as effective as 10 days of therapy; it was very effective in women who were less-than-or-equal-to 65 years. Bacteriuria resolved spontaneously within 14 days after catheter removal more commonly in women who were less-than-or-equal-to 65 years and both types of therapy were less effective in older women.