CHEMISTRY OF THE BURSERACEAE .15. MANSUMBINANE DERIVATIVES FROM STEM BARK OF COMMIPHORA-KUA

被引：18

作者：

PROVAN, GJ

GRAY, AI

WATERMAN, PG

机构：

[1] Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 06期

关键词：

COMMIPHORA-KUA; BURSERACEAE; 17-OCTANORDAMMARANES; MANSUMBIN-13(17)-EN-3,16-DIONE; 3-BETA-HYDROXYMANSUMBIN-13(17)-EN-16-ONE; 3,4-SECO-MANSUMBIN-5(28),13(17)-DIEN-16-ONE-3-OIC ACID; 16-HYDROPEROXYMANSUMBIN-13(17)-EN DERIVATIVES; HMBC NMR;

D O I：

10.1016/0031-9422(92)80364-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The stem bark of Commiphora kua has yielded three unstable C22 compounds which rapidly degraded to give artefacts identified as mansumbin-13(17)-en-3,16-dione (4-alpha,4-beta,8-beta,10-beta,14-alpha-pentamethyl-5-alpha-gon-13(17)-en-3,16-dione), 3-beta-hydroxymansumbin-13(17)-en-16-one, and 16-oxo-3,4-seco-mansumbin-4(28),13(17)-dien-3-oic acid. Spectroscopic evidence is advanced suggesting that the unstable parent compounds were the corresponding 16-hydroperoxides. Structure elucidation made considerable use of heteronuclear multiple-bond coherence spectroscopy (HMBC).

引用

页码：2065 / 2068

页数：4

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