A TBP COMPLEX ESSENTIAL FOR TRANSCRIPTION FROM TATA-LESS BUT NOT TATA-CONTAINING RNA POLYMERASE-III PROMOTERS IS PART OF THE TFIIIB FRACTION

被引:144
作者
LOBO, SM
TANAKA, M
SULLIVAN, ML
HERNANDEZ, N
机构
[1] Cold Spring Harbor Laboratory Cold Spring Harbor
关键词
D O I
10.1016/0092-8674(92)90397-U
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The TATA box-binding protein TBP directs transcription by all three eukaryotic RNA polymerases. In mammalian cells, TBP is found in at least three different complexes: SL1, D-TFIID, and B-TFIID. While SL1 and D-TFIID are involved in RNA polymerase I and II transcription, respectively, no unique function has been assigned to the B-TFIID complex. Here we show that the TFIIIB fraction required for RNA polymerase III transcription contains two separable components, one of which is a TBP-containing complex that may correspond to B-TFIID. For transcription of TATA-less RNA polymerase III genes such as the VAI, 5S, and 7SL genes, this complex cannot be replaced by either TBP alone or the D-TFIID complex. In contrast, TBP alone is active for basal transcription from the TATA-containing U6 promoter. This indicates different requirements for recruiting TBP to TATA-less and TATA-containing RNA polymerase III promoters.
引用
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页码:1029 / 1040
页数:12
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