NEURAL STEM-CELLS FOR CNS TRANSPLANTATION

被引:26
作者
BAETGE, EE
机构
[1] Cytotherapeutics, Inc., Providence, Rhode Island
来源
ALZHEIMERS DISEASE: AMYLOID PRECUSOR PROTEINS, SIGNAL TRANSDUCTION, AND NEURONAL TRANSPLANTATION | 1993年 / 695卷
关键词
D O I
10.1111/j.1749-6632.1993.tb23068.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neurodegenerative disorders such as Parkinson's, Alzheimer's, and Huntington's disease are becoming ever more prominent in our society. A direct approach towards therapeutic treatment of these diseases is through replacement therapy where normal tissue is transplanted back to the nervous system. Recently, significant progress has been achieved with transplants in Parkinson's disease, but the process is heavily dependent on an unstable and problematic source of fetal tissue. Neural stem cells may become the tissue/cell source necessary for developing the therapeutic potential of neural transplantation. Stem cells are self-renewing, multipotent and could provide a well-characterized and clean source of transplantable material. A number of new in vitro approaches have led to the development of continuously propagated stem cells that are potential candidates for nervous system transplantation. These include oncogene-induced immortalization and growth-factor stimulation of naturally occurring central and peripheral nervous system stem cells. The nature of these cells and their suitability for transplantation into the CNS will be evaluated.
引用
收藏
页码:285 / 291
页数:7
相关论文
共 27 条
[1]   EGF AND TGF-ALPHA STIMULATE RETINAL NEUROEPITHELIAL CELL-PROLIFERATION INVITRO [J].
ANCHAN, RM ;
REH, TA ;
ANGELLO, J ;
BALLIET, A ;
WALKER, M .
NEURON, 1991, 6 (06) :923-936
[2]   IMMORTALIZATION OF MOUSE NEURAL PRECURSOR CELLS BY THE C-MYC ONCOGENE [J].
BARTLETT, PF ;
REID, HH ;
BAILEY, KA ;
BERNARD, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (09) :3255-3259
[3]   PROLIFERATION AND DIFFERENTIATION OF NEURONAL STEM-CELLS REGULATED BY NERVE GROWTH-FACTOR [J].
CATTANEO, E ;
MCKAY, R .
NATURE, 1990, 347 (6295) :762-765
[4]   IMMORTALIZATION OF BIPOTENTIAL AND PLASTIC GLIO-NEURONAL PRECURSOR CELLS [J].
EVRARD, C ;
BORDE, I ;
MARIN, P ;
GALIANA, E ;
PREMONT, J ;
GROS, F ;
ROUGET, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3062-3066
[5]  
FREDERIKSEN K, 1988, J NEUROSCI, V8, P1144
[6]   SURVIVAL OF IMPLANTED FETAL DOPAMINE CELLS AND NEUROLOGIC IMPROVEMENT 12 TO 46 MONTHS AFTER TRANSPLANTATION FOR PARKINSONS-DISEASE [J].
FREED, CR ;
BREEZE, RE ;
ROSENBERG, NL ;
SCHNECK, SA ;
KRIEK, E ;
QI, JX ;
LONE, T ;
ZHANG, YB ;
SNYDER, JA ;
WELLS, TH ;
RAMIG, LO ;
THOMPSON, L ;
MAZZIOTTA, JC ;
HUANG, SC ;
GRAFTON, ST ;
BROOKS, D ;
SAWLE, G ;
SCHROTER, G ;
ANSARI, AA .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (22) :1549-1555
[7]   ANTIGENIC AND FUNCTIONAL-CHARACTERIZATION OF A RAT CENTRAL NERVOUS-SYSTEM DERIVED CELL-LINE IMMORTALIZED BY A RETROVIRAL VECTOR [J].
GELLER, HM ;
DUBOISDALCQ, M .
JOURNAL OF CELL BIOLOGY, 1988, 107 (05) :1977-1986
[8]   BRAIN BASIC FIBROBLAST GROWTH-FACTOR STIMULATES THE PROLIFERATION OF RAT NEURONAL PRECURSOR CELLS-INVITRO [J].
GENSBURGER, C ;
LABOURDETTE, G ;
SENSENBRENNER, M .
FEBS LETTERS, 1987, 217 (01) :1-5
[9]  
HALL PA, 1989, DEVELOPMENT, V106, P619
[10]   MOLECULAR-BASES OF THE IMMUNE-RESPONSE TO NEURAL ANTIGENS [J].
LAMPSON, LA .
TRENDS IN NEUROSCIENCES, 1987, 10 (05) :211-216