VALPROATE ACUTE ADMINISTRATION, EEG EPILEPTIC ABNORMALITIES, AND AMMONEMIA

被引：10

作者：

SANNITA, WG

机构：

[1] CNR,CTR CEREBRAL NEUROPHYSIOL,GENOA,ITALY

[2] SUNY STONY BROOK,DEPT PSYCHIAT,STONY BROOK,NY 11794

[3] UNIV GENOA,INST NEUROPHYSIOPATHOL,CTR NEUROACT DRUGS,I-16132 GENOA,ITALY

来源：

NEUROLOGY | 1992年 / 42卷 / 10期

关键词：

D O I：

10.1212/WNL.42.10.2003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Acute, oral administration of 14.3 to 37.5 mg/kg magnesium valproate (peak serum concentrations, 65 to 139 mug/ml) increases spike-wave frequency at 2, 3, 4, and 5 hours postdrug, in the absence of hyperammonemia or significant correlations with ammonemia fluctuations. This observation suggests a direct role of valproate on neural activity.

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页码：2003 / 2005

页数：3

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