DEPHOSTATIN, A NOVEL PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR PRODUCED BY STREPTOMYCES .2. STRUCTURE DETERMINATION

被引：34

作者：

KAKEYA, H

IMOTO, M

TAKAHASHI, Y

NAGANAWA, H

TAKEUCHI, T

UMEZAWA, K

机构：

[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT APPL CHEM,3-14-1 HIYOSHI,KOHOKU KU,YOKOHAMA,KANAGAWA 223,JAPAN

[2] INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 11期

关键词：

D O I：

10.7164/antibiotics.46.1716

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dephostatin, a novel tyrosine phosphatase inhibitor, was isolated from the culture broth of Streptomyces sp. MJ742-NF5. The structure was elucidated to be 2-(N-methyl-N-nitroso)hydroquinone by spectral and chemical analyses of dephostatin and its derivatives.

引用

页码：1716 / 1719

页数：4