A NEW SCREEN FOR ANTI-INFLAMMATORY AGENTS - ESTIMATION OF RAT SERUM ACUTE PHASE-ALPHA-2-MACROGLOBULIN LEVELS USING AN ELECTRO-IMMUNOASSAY

被引：15

作者：

BALDO, BA ^{[1
]}

CHOW, SC ^{[1
]}

EUERS, C ^{[1
]}

机构：

[1] ROCHE RES INST MARINE PHARMACOL, DEE WHY, NSW 2099, AUSTRALIA

来源：

AGENTS AND ACTIONS | 1981年 / 11卷 / 05期

关键词：

D O I：

10.1007/BF02004710

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Induction of .alpha.2-macroglobulin acute phase protein in rats by the injection of turpentine revealed strain and sex differences in the amounts of this protein detected in sera by rocket immunoelectrophoresis. Studies in vivo with a wide variety of drugs showed that non-steroidal anti-inflammatory drugs (NSAID) such as aspirin, indomethacin and BW 755C [3-amino-1-[m-(trifluoromethyl)-phenyl]-2-pyrazoline] as well as colchicine, clofibrate and clozic inhibited serum concentrations of the acutephase protein 48 h after turpentine injection. This procedure offers a new and convenient screen for assessing NSAID and the method may be of value as a screen for new clozic-like compounds with anti-rheumatic activity. The possibility that the NSAID are inhibiting a humoral factor initiated by the inflammatory stimulus and that the humoral factor is a metabolite of arachidonic acid is discussed.

引用

页码：482 / 489

页数：8

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