POTASSIUM-STIMULATED RELEASE OF NITRIC-OXIDE FROM CEREBELLAR SLICES

被引：27

作者：

DICKIE, BGM ^{[1
]}

LEWIS, MJ ^{[1
]}

DAVIES, JA ^{[1
]}

机构：

[1] UNIV COLL CARDIFF,DEPT PHARMACOL & THERAPEUT,CARDIFF CF4 4XN,S GLAM,WALES

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 101卷 / 01期

关键词：

D O I：

10.1111/j.1476-5381.1990.tb12078.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study shows that nitric oxide release can be evoked from intact neuronal tissue. Stimulation of rat cerebellar slices for 4 min with 50 mM potassium significantly increased the release of nitric oxide and glutamate and was associated with a rise in the guanosine 3':5'-cyclic monophosphate (cyclic GMP) content of the tissue. Nitric oxide levels in the perfusate increased from 160 to 262 parts per billion. It is suggested that an increased release of endogenous glutamate in the slice, induced by exposure to potassium, may mediate the release of nitric oxide.

引用

页码：8 / 9

页数：2

共 10 条

[1] A NOVEL SUPERFUSION CHAMBER FOR THE MEASUREMENT OF ENDOGENOUS GLUTAMATE RELEASE FROM CEREBELLAR SLICES
BARNES, S
LEIGHTON, GE
DAVIES, JA
[J]. JOURNAL OF NEUROSCIENCE METHODS, 1988, 23 (01) : 57 - 61
[2] ABSENCE OF N-METHYL-D-ASPARTATE RECEPTORS ON OVINE CEREBRAL MICROVESSELS
BEART, PM
SHEEHAN, KAM
MANALLACK, DT
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (06) : 879 - 882
[3] BRADYKININ-INDUCED INCREASES IN CYTOSOLIC CALCIUM AND IONIC CURRENTS IN CULTURED BOVINE AORTIC ENDOTHELIAL-CELLS
COLDENSTANFIELD, M
SCHILLING, WP
RITCHIE, AK
ESKIN, SG
NAVARRO, LT
KUNZE, DL
[J]. CIRCULATION RESEARCH, 1987, 61 (05) : 632 - 640
[4] ENDOTHELIUM-DERIVED RELAXING FACTOR AND NITROPRUSSIDE COMPARED IN NORADRENALINE-CONTRACTED AND K+-CONTRACTED RABBIT AND RAT AORTAE
COLLINS, P
HENDERSON, AH
LANG, D
LEWIS, MJ
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1988, 400 : 395 - 404
[5] A CHEMI-LUMINESCENT TECHNIQUE FOR THE DETERMINATION OF NANOMOLAR CONCENTRATIONS OF NITRATE AND NITRITE IN SEA-WATER
GARSIDE, C
[J]. MARINE CHEMISTRY, 1982, 11 (02) : 159 - 167
[6] CELLULAR-ORIGINS OF CYCLIC-GMP RESPONSES TO EXCITATORY AMINO-ACID RECEPTOR AGONISTS IN RAT CEREBELLUM INVITRO
GARTHWAITE, J
GARTHWAITE, G
[J]. JOURNAL OF NEUROCHEMISTRY, 1987, 48 (01) : 29 - 39
[7] ENDOTHELIUM-DERIVED RELAXING FACTOR RELEASE ON ACTIVATION OF NMDA RECEPTORS SUGGESTS ROLE AS INTERCELLULAR MESSENGER IN THE BRAIN
GARTHWAITE, J
CHARLES, SL
CHESSWILLIAMS, R
[J]. NATURE, 1988, 336 (6197) : 385 - 388
[8] EXCITATORY AMINO-ACIDS AND CEREBROVASCULAR TONE
HARDEBO, JE
WIELOCH, T
KAHRSTROM, J
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1989, 136 (03): : 483 - 485
[9] FORMATION OF NITRIC-OXIDE FROM L-ARGININE IN THE CENTRAL NERVOUS-SYSTEM - A TRANSDUCTION MECHANISM FOR STIMULATION OF THE SOLUBLE GUANYLATE-CYCLASE
KNOWLES, RG
PALACIOS, M
PALMER, RMJ
MONCADA, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) : 5159 - 5162
[10] VASCULAR ENDOTHELIAL-CELLS SYNTHESIZE NITRIC-OXIDE FROM L-ARGININE
PALMER, RMJ
ASHTON, DS
MONCADA, S
[J]. NATURE, 1988, 333 (6174) : 664 - 666

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