PREDICTION OF PEAK PENICILLIN AND CEPHALOSPORIN CONCENTRATIONS IN CANINE SERUM AS DERIVED FROM INVITRO SERUM AND TISSUE QUANTITATIVE PROTEIN-BINDING

被引：15

作者：

PETERSON, LR ^{[1
]}

GERDING, DN ^{[1
]}

MCLINN, D ^{[1
]}

HALL, WH ^{[1
]}

机构：

[1] UNIV MINNESOTA, SCH MED, MINNEAPOLIS, MN 55455 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1979年 / 5卷 / 02期

关键词：

D O I：

10.1093/jac/5.2.219

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Peak serum concentrations of 4 penicillin and 2 cephalosporin antibiotics were predicted from quantitative antibiotic binding to serum and tissue proteins in dogs. Predicted total peak serum antibiotic levels varied from 5.1 mg/100 ml for the 17.0% canine serum-bound methicillin to 16.5 mg/100 ml for the 83.6% serum-bound nafcillin. Actual peak antibiotic concentrations measured following rapid i.v. injection into dogs agreed with predicted concentrations for all drugs except nafcillin.

引用

收藏

页码：219 / 227

页数：9

相关论文

共 25 条

[1]

BARZA M, 1976, Clinical Pharmacokinetics, V1, P297

[2] PHARMACOKINETIC MODEL FOR SALICYLATE IN CEREBROSPINAL-FLUID, BLOOD, ORGANS, AND TISSUES [J].

CHEN, CN ;

COLEMAN, DL ;

ANDRADE, JD ;

TEMPLE, AR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (01) :38-45

[3] SIGNIFICANCE OF SERUM-PROTEIN AND TISSUE BINDING OF ANTIMICROBIAL AGENTS [J].

CRAIG, WA ;

KUNIN, CM .

ANNUAL REVIEW OF MEDICINE, 1976, 27 :287-300

[4] OVERVIEW OF DRUG-PROTEIN BINDING [J].

GILLETTE, JR .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1973, 226 (NOV26) :6-17

[5] PHARMACOKINETICS OF CEPHALEXIN - EVALUATION OF ONE-COMPARTMENT AND 2-COMPARTMENT MODEL PHARMACOKINETICS [J].

GREENE, DS ;

FLANAGAN, DR ;

QUINTILIANI, R ;

NIGHTINGALE, CH .

JOURNAL OF CLINICAL PHARMACOLOGY, 1976, 16 (5-6) :257-264

[6] PHYSIOLOGICAL PERFUSION MODEL FOR CEPHALOSPORIN ANTIBIOTICS .1. MODEL SELECTION BASED ON BLOOD DRUG CONCENTRATIONS [J].

GREENE, DS ;

QUINTILIANI, R ;

NIGHTINGALE, CH .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (02) :191-196

[7]

Keen P., 1971, BIOCHEM PHARMACOL, V26, P213, DOI 10.1007/978-3-642-65052-9_10

[8] MECHANISMS RESPONSIBLE FOR PLASMA LEVELS OF NAFCILLIN LOWER THAN THOSE OF OXACILLIN [J].

KIND, AC ;

TUPASI, TE ;

STANDIFORD, HC ;

KIRBY, WMM .

ARCHIVES OF INTERNAL MEDICINE, 1970, 125 (04) :685-+

[9] DRUG-THERAPY - BINDING OF DRUGS TO SERUM-ALBUMIN .1. [J].

KOCHWESER, J ;

SELLERS, EM .

NEW ENGLAND JOURNAL OF MEDICINE, 1976, 294 (06) :311-316

[10] DRUG-THERAPY .2. BINDING OF DRUGS TO SERUM-ALBUMIN [J].

KOCHWESER, J ;

SELLERS, EM .

NEW ENGLAND JOURNAL OF MEDICINE, 1976, 294 (10) :526-531