DETERMINATION OF METRIFONATE AND DICHLORVOS IN WHOLE-BLOOD USING GAS-CHROMATOGRAPHY AND GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：16

作者：

VILLEN, T ^{[1
]}

ABDI, YA ^{[1
]}

ERICSSON, O ^{[1
]}

GUSTAFSSON, LL ^{[1
]}

SJOQVIST, F ^{[1
]}

机构：

[1] SOMALI NATL UNIV,FAC MED,DEPT PHARMACOL,MUQDISHO,SOMALIA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 529卷 / 02期

关键词：

D O I：

10.1016/S0378-4347(00)83837-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Analytical methods for determining metrifonate and dichlorvos in whole blood and a sampling procedure suitable for pharmacokinetic studies in man are described. Metrifonate concentrations were determined after chloroform extraction using gas chromatography-nitrogen-phosphorus detection. The within-assay coefficients of variation were 4 and 9% at 19.4 and 0.8 μmol/l (limits of determination), respectively. Dichlorvos was determined using gas chromatography-mass spectrometry of toluene extracts. The within-assay coefficients of variation were 2 and 5% at 225 and 50 nmol/l (limits of determination), respectively. Since both substances are chemically unstable, the blood was collected by dripping it directly from the vein into 0.74 M phosphoric acid. © 1990.

引用

页码：309 / 317

页数：9

共 15 条

[1] POOR PATIENT COMPLIANCE REDUCES THE EFFICACY OF METRIFONATE TREATMENT OF SCHISTOSOMA-HAEMATOBIUM IN SOMALIA [J].

ABDI, YA ;

GUSTAFSSON, LL .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 36 (02) :161-164

[2]

ABDI YA, 1990, IN PRESS B WHO, V68

[3]

ABDI YA, 1987, EUR J CLIN PHARMACOL, V32, P437

[4] A RAPID AND SENSITIVE QUANTITATION OF DIPTEREX IN SERUM BY SOLID-PHASE EXTRACTION AND GAS-CHROMATOGRAPHY WITH FLAME THERMIONIC DETECTION [J].

AMENO, K ;

FUKE, C ;

AMENO, S ;

KIRIU, T ;

IJIRI, I .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1989, 13 (03) :150-151

[5] DIALKYL ALPHA-HYDROXYPHOSPHONATES DERIVED FROM CHLORAL [J].

BARTHEL, WF ;

GIANG, PA ;

HALL, SA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (16) :4186-4187

[6]

Gustafsson LL, 1987, HDB DRUGS TROPICAL P

[7]

LEBRUN A, 1960, Bull World Health Organ, V22, P579

[8]

LORENZ W., 1955, JOUR AMER CHEM SOC, V77, P2554, DOI 10.1021/ja01614a061

[9] TOXIC ACTION OF DIPTEREX AND DDVP TO THE HOUSE FLY [J].

METCALF, RL ;

FUKUTO, TR ;

MARCH, RB .

JOURNAL OF ECONOMIC ENTOMOLOGY, 1959, 52 (01) :44-49

[10]

Miyamoto J., 1959, Botyu-Kagaku Tokyo, V24, P130

← 1 2 →