THE TRIFLUOROMETHYLATION OF CHLOROAROMATICS USING THE COPPER-CF2BR2 - DIALKYLAMIDE REACTION SYSTEM

被引：25

作者：

CLARK, JH

DENNESS, JE

MCCLINTON, MA

WYND, AJ

机构：

[1] Department of Chemistry, University of York, York

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1990年 / 50卷 / 03期

关键词：

D O I：

10.1016/S0022-1139(00)85007-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The in situ generation of CuCF3 from the reaction of copper, dibromodifluoromethane and either N,N-dimethylformamide or N,N-dimethylacetamide (Burton's reagent) has been used for the direct substitution of chlorine by CF3 in a number of aromatic substrates. Particular attention has been paid to the effects of ring substituents on the efficiency of reaction.

引用

页码：411 / 426

页数：16

共 13 条

[1]

BURTON DJ, 1986, J AM CHEM SOC, V108, P832

[2] THE DIRECT TRIFLUOROMETHYLATION OF ARYL CHLORIDES USING BURTON REAGENT [J].