ORNITHINE AMINOTRANSFERASE-RELATED SEQUENCES MAP TO 2 NONADJACENT INTERVALS ON THE HUMAN X-CHROMOSOME SHORT ARM

被引：30

作者：

LAFRENIERE, RG

GERAGHTY, MT

VALLE, D

SHOWS, TB

WILLARD, HF

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,HOWARD HUGHES MED INST,BALTIMORE,MD 21205

[2] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT HUMAN GENET,BUFFALO,NY 14263

来源：

GENOMICS | 1991年 / 10卷 / 01期

关键词：

D O I：

10.1016/0888-7543(91)90512-D

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Using a panel of human/rodent somatic cell hybrids segregating human X/autosome translocations and deletions, we have refined the localization of the X-linked sequences homologous to ornithine-δ-aminotransferase (OAT), the structural locus for which (OAT) maps to chromosome 10. OAT-related ("-like") (OATL) sequences mapped to two nonadjacent intervals: OATL1 mapped to Xp11.3-p11.23, while OATL2 mapped to Xp11.22-p11.21. X-linked OATL1 sequences polymorphic for ScaI and StuI map to the more distal interval in Xp11.3-p11.23. These results should help guide long-range cloning and mapping studies, as well as refine the genetic linkage map in this region of the X chromosome. © 1991.

引用

页码：276 / 279

页数：4

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