ACUTE THEOPHYLLINE INTOXICATION

被引：7

作者：

ANDERSON, W

YOUL, B

MACKAY, JR

机构：

[1] Institute for Medical Research, Melbourne, Clinical Research Unit Walter and Eliza Hall

[2] Royal Melbourne Hospital, Melbourne

来源：

ANNALS OF EMERGENCY MEDICINE | 1991年 / 20卷 / 10期

关键词：

overdose; theophylline;

D O I：

10.1016/S0196-0644(05)81394-0

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We describe a case of intentional acute theophylline intoxication with cardiac, cerebral, and gastrointestinal features of moderate-to-severe toxicity. The unusual metabolic and hematologic sequelae included hypokalemia, hyperglycemia, metabolic acidosis, extreme neutrophilia, increased creatinine levels attributed to muscle damage, and hematuria. The implications of these unusual findings for the management of acute theophylline intoxication include the recognition that these effects can be due to intoxication per se and do not necessarily indicate a primary endocrine disorder or infection.

引用

页码：1143 / 1145

页数：3

共 25 条

[1]

Jacobs, Senior, Kessler, Clinical experience with theophylline: Relationships between dosage, serum concentration and toxicity, JAMA, 235, pp. 1983-1986, (1976)

[2]

Zwillich, Sutton, Neff, Et al., Theophylline-induced seizures in adults: Correlation with serum concentrations, Ann Intern Med, 82, pp. 784-787, (1975)

[3]

Dawson, Whyte, The assessment and treatment of theophylline poisoning, Med J Aust, 151, pp. 689-693, (1989)

[4]

Keamey, Manoguerra, Curtis, Et al., Theophylline toxicity and the beta adrenergic system, Annals of Internal Medicine, 102, pp. 766-769, (1985)

[5]

Hendeles, Bighley, Richardson, Et al., Frequent toxicity from IV aminophylline infusions in critically ill patients, Drug Intell Clin Pharmacol, 11, pp. 12-18, (1977)

[6]

Horowitz, Spear, Moore, Et al., Effects of aminophylline on the threshold for initiating ventricular fibrillation during respiratory failure, Am J Cardiol, 35, pp. 376-379, (1975)

[7]

Olson, Benowitz, Woo, Et al., Theophylline overdose: Acute single ingestion versus chronic repeated overmedication, Am J Emerg Med, 3, pp. 386-394, (1985)

[8]

Amitai, Lovejoy, Characteristics of vomiting associated with acute sustained release theophylline poisoning, Clin Toxicol, 25, pp. 539-554, (1987)

[9]

Halliwell, Berry, Theophylline poisoning in adults, BMJ, 2, (1979)

[10]

Rose, Theophylline toxicity, West J Med, 130, pp. 466-467, (1979)

← 1 2 3 →