THERMOSPRAY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY FOR THE CHARACTERIZATION OF SULFATE ESTER CONJUGATES

被引：5

作者：

BOWERS, GD

HIGTON, DM

MANCHEE, GR

OXFORD, J

SAYNOR, DA

机构：

[1] Department of Biochemical Pharmacology, Glaxo Group Research Limited, Ware, Hertfordshire SG12 0DP, Part Road

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 554卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(01)88447-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Formation of polar conjugates is a well documented metabolic pathway for xenobiotics containing phenolic hydroxyl groups. This paper describes the analysis of two sulphate ester conjugates by fast atom bombardment mass spectrometry and thermospray liquid chromatography-mass spectrometry. Thermospray liquid chromatography-mass spectrometry proved the more successful technique for obtaining the molecular weight of the intact conjugate, but only by removal of the buffer from the high-performance liquid chromatography eluent.

引用

页码：175 / 180

页数：6

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