EXPRESSION OF TRANSFORMING GROWTH-FACTOR TYPE BETA ON HUMAN EPIDERMAL DENDRITIC CELLS

被引：37

作者：

GRUSCHWITZ, MS

HORNSTEIN, OP

机构：

[1] Department of Dermatology, Medical School, University of Erlangen, Nuremberg

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1992年 / 99卷 / 01期

关键词：

D O I：

10.1111/1523-1747.ep12611890

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Our study demonstrates that epidermal Langerhans cells (LC) of healthy human skin produce Transforming growth factor-beta (TGF-beta). This multipotent mediator might keep the immunocompetent LC in an "immature" stage, in which they are able to capture and process antigen. Development to potent antigen-presenting cells would become possible after migration from the epidermal network to the draining lymph node to stimulate (auto-)reactive T-cell clones.

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页码：114 / 116

页数：3

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