LIPASE-CATALYZED KINETIC RESOLUTION OF 2,3-EPOXY-8-METHYL-1-NONANOL, THE KEY INTERMEDIATE IN THE SYNTHESIS OF THE GYPSY-MOTH PHEROMONE

被引：12

作者：

FUKUSAKI, E

SENDA, S

NAKAZONO, Y

YUASA, H

OMATA, T

机构：

[1] Medical and Membrane Research Laboratory, Nitto Denko Co., Ibaraki, Osaka, 567, 1-1-2, Shimohozumi

来源：

JOURNAL OF FERMENTATION AND BIOENGINEERING | 1992年 / 73卷 / 04期

关键词：

D O I：

10.1016/0922-338X(92)90183-U

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lipase-catalyzed enantioselective acylation of (+/-)-2,3-epoxy-8-methyl-1-nonanol with acetic anhydride in diisopropyl ether yielded (2S, 3R)-1-acetoxy-2,3-epoxy-8-methylnonane with 79% enantiomeric excess (ee). The optical purity of the epoxy ester was improved up to 95% ee by a second step of lipase-catalyzed enantioselective alcoholysis in diisopropyl ether.

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页码：280 / 283

页数：4

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