CHIRAL, PIPERIDINE-BASED ANALOGS OF AF64A AND ACETYLCHOLINE

被引：8

作者：

HUH, N ^{[1
]}

THOMPSON, CM ^{[1
]}

机构：

[1] LOYOLA UNIV,DEPT CHEM,CHICAGO,IL 60626

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80426-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chiral analogues of acetylcholine and AF64A were prepared from l-glutamate acid via the central intermediate, (S)-3-acetoxypiperidine.

引用

收藏

页码：1551 / 1554

页数：4

相关论文

共 19 条

[1] CONFORMATIONALLY RIGID ANALOGUES OF ACETYLCHOLINE
ARMSTRONG, PD
CANNON, JG
LONG, JP
[J]. NATURE, 1968, 220 (5162) : 65 - +
[2] ARMSTRONG PD, 1970, J MED CHEM, V13, P1037
[3] EFFECT OF ETHYLCHOLINE MUSTARD ON CHOLINE DEHYDROGENASE AND OTHER ENZYMES OF CHOLINE METABOLISM
BARLOW, P
MARCHBANKS, RM
[J]. JOURNAL OF NEUROCHEMISTRY, 1984, 43 (06) : 1568 - 1573
[4] SIMPLE TOTAL SYNTHESIS OF (+/-)-PERHYDROHISTRIONICOTOXIN
COREY, EJ
ARNETT, JF
WIDIGER, GN
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (02) : 430 - 431
[5] alpha,beta-Unsaturated aminoketones VIII Reaction of primary amines with 1,3-diketones and bromine derivatives of derivatives of benazlacetophenone ethylene imines
Cromwell, NH
Babson, RD
Harris, CE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1943, 65 : 312 - 315
[6] (S)-TETRAHYDRO-5-OXO-2-FURANCARBOXYLIC ACID - A CHIRAL DERIVATIZING REAGENT FOR ASYMMETRIC ALCOHOLS
DOOLITTLE, RE
HEATH, RR
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (26) : 5041 - 5050
[7] GILROY J, 1982, BASIC NEUROLOGY, P169
[8] HANIN I, 1983, BANBURY REPORT, V15, P243
[9] HO PT, 1983, SYNTHESIS-STUTTGART, P462
[10] TOSYLATION OF ALCOHOLS
KABALKA, GW
VARMA, M
VARMA, RS
SRIVASTAVA, PC
KNAPP, FF
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (12) : 2386 - 2388