THE ROLE OF SEROTONIN IN SCHIZOPHRENIA - AN OVERVIEW OF THE NOMENCLATURE, DISTRIBUTION AND ALTERATIONS OF SEROTONIN RECEPTORS IN THE CENTRAL-NERVOUS-SYSTEM

被引：55

作者：

OHUOHA, DC ^{[1
]}

HYDE, TM ^{[1
]}

KLEINMAN, JE ^{[1
]}

机构：

[1] ST ELIZABETH HOSP,DEPT PSYCHIAT,WASHINGTON,DC 20032

来源：

PSYCHOPHARMACOLOGY | 1993年 / 112卷 / 01期

关键词：

5-HT RECEPTORS; CLASSIFICATION; NOMENCLATURE; POSTMORTEM STUDIES; SCHIZOPHRENIA;

D O I：

10.1007/BF02245003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin is a neurotransmitter that is widely distributed throughout the central nervous system. The role of serotonin in schizophrenia is still unclear. Postmortem studies of serotonin receptor subtypes in schizophrenia have been inconclusive for the most part. The most promising findings involve a reduction in 5-HT2 receptors and 5-HT reuptake sites in the prefrontal cortex of schizophrenic patients. In this paper we review the function, distribution and pharmacological characteristics of serotonin receptors. Postmortem studies are also reviewed, focusing upon the role of these receptors in schizophrenia.

引用

页码：S5 / S15

页数：11

共 177 条

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[2]

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