IL-2 RECEPTOR-ALPHA CHAIN EXPRESSION DURING EARLY B-LYMPHOCYTE DIFFERENTIATION

被引：43

作者：

CHEN, JZ

MA, A

YOUNG, F

ALT, FW

机构：

[1] HARVARD UNIV,CHILDRENS HOSP,SCH MED,HOWARD HUGHES MED INST,DEPT GENET,BOSTON,MA 02115

[2] CTR BLOOD RES,BOSTON,MA 02115

来源：

INTERNATIONAL IMMUNOLOGY | 1994年 / 6卷 / 08期

关键词：

ACTIVATED B CELLS IG; IMMATURE B CELLS; MATURE B CELLS; PRE-B; PRO-B; RAG; REARRANGEMENT; THYMOCYTE DIFFERENTIATION;

D O I：

10.1093/intimm/6.8.1265

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The IL-2/IL-2 receptor (IL-2R) has been studied intensively because of its potential function in the development and regulation of the immune system. The IL-2R alpha chain has been shown to be expressed on CD4(-)CD8(-) thymocytes and activated T and a cells. In this report, we show that IL-2R alpha is also expressed on precursor a cells in the bone marrow. Its expression is initiated by functional rearrangement and expression of Ig mu heavy chain gene and is dawn-regulated when immature a cells mature and express IgD. Its potential function in early B cell differentiation is discussed in comparison with its role in thymocyte differentiation.

引用

页码：1265 / 1268

页数：4

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