THE ROLE OF ATP-SENSITIVE POTASSIUM CHANNELS IN MYOCARDIAL PROTECTION

被引：13

作者：

CASON, BA ^{[1
]}

GORDON, HJ ^{[1
]}

AVERY, EG ^{[1
]}

HICKEY, RF ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT ANESTHESIA,SAN FRANCISCO,CA 94143

来源：

JOURNAL OF CARDIAC SURGERY | 1995年 / 10卷 / 04期

关键词：

D O I：

10.1111/j.1540-8191.1995.tb00675.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several factors have pointed to a potential link between ATP sensitive potassium channel activation in ventricular myocytes and the phenomenon of myocardial preconditioning. Preconditioning can be blocked by adenosine antagonists, and is mimicked by adenosine A(1)-receptor agonists. A portion of the physiological action of adenosine is, however attributable to adenosine actions on K-ATP channels. The adenosine A(1) receptor is reported to be linked to the K-ATP channel in rat ventricular myocytes by a G-protein mechanism. This article will review the current status of work regarding the role of K-ATP channels in myocardial preconditioning and will highlight recent work addressing the role of anesthetic effects in these studies. Recent reports and work from our laboratory reveal that several commonly used anesthetic drugs either have direct effects on K-ATP channels (barbiturates) or have prominent physiological effects that are modulated in large part by K-ATP channels (volatile anesthetics halothane and isoflurane).

引用

页码：441 / 444

页数：4

共 32 条

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