RESPONSES OF MITOCHONDRIAL SUPEROXIDE-DISMUTASE, CATALASE AND GLUTATHIONE-PEROXIDASE ACTIVITIES TO AGING

被引：79

作者：

NOHL, H ^{[1
]}

HEGNER, D ^{[1
]}

SUMMER, KH ^{[1
]}

机构：

[1] GESELLSCHAFT STRAHLEN & UMWELTFORSCH MUNCHEN, INST TOXIKOL & BIOCHEM, ABT TOXIKOL, D-8042 NEUHERBERG, FED REP GER

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1979年 / 11卷 / 03期

关键词：

D O I：

10.1016/0047-6374(79)90050-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The previous observation (Eur. J. Biochem., 82 (1978) 563-567) that age-dependent accumulation of lipid peroxides follows as a consequence of increased radical formation in mitochondria has prompted an examination of the response of a set of protective enzymes to the above situation. Levels of mitochondrial catalase activity as well as selenium-dependent glutathione peroxidase activity were found to be increased with age, while superoxide dismutase activity remained unchanged. No selenium-independent glutathione peroxidase activity could be detected either in preparations from young 3-month-old controls or in preparations from 2-year-old rats. Both the relatively high and unchanged levels of reduced glutathione and kinetic considerations suggest that glutathione peroxidase is preferentially involved in lipid peroxide metabolism, while catalase predominantly metabolizes mitochondrial H2O2. © 1979.

引用

页码：145 / 151

页数：7

共 24 条

[1] SUBSTRATE-INDUCED CHEMILUMINESCENCE OF XANTHINE OXIDASE AND ALDEHYDE OXIDASE [J].