ERYTHROSIN-B INHIBITION OF NEUROTRANSMITTER ACCUMULATION BY RAT-BRAIN HOMOGENATE

被引：56

作者：

LOGAN, WJ

SWANSON, JM

机构：

[1] Division of Neurology, Hospital for Sick Children, Toronto

来源：

SCIENCE | 1979年 / 206卷 / 4416期

关键词：

D O I：

10.1126/science.39341

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A mixture of seven food dyes inhibited the accumulation of eight neurotransmitters or neurotransmitter precursors by rat brain homogenate. At a low concentration (amicrogram per milliliter), erythrosin B (FD&C red 3) was the only dye that inhibited dopamine accumulation. Erythrosin also was effective in decreasing the accumulation of all the other transmitter substances, suggesting that the inhibition is nonspecific and probably secondary to general membrane alteration. Copyright © 1979 AAAS.

引用

页码：363 / 364

页数：2

共 13 条

[1]

AUGUSTINE GJ, 1977, SOC NEUR ABSTR, V3, P370

[2]

AUGUSTINE GJ, 1966, SOC NEUR ABSTR, V4, P367

[3] AMINO-ACID NEUROTRANSMITTER CANDIDATES - SODIUM-DEPENDENT HIGH-AFFINITY UPTAKE BY UNIQUE SYNAPTOSOMAL FRACTIONS [J].