CADMIUM-BINDING IN THE PREGNANT AND FETAL RAT

被引：7

作者：

KELMAN, BJ

OZGA, JA

WALTER, BK

SASSER, LB

机构：

[1] Comparative Animal Research Laboratory, Oak Ridge, TN 37830

来源：

TOXICOLOGY LETTERS | 1979年 / 4卷 / 03期

关键词：

D O I：

10.1016/0378-4274(79)90123-1

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A cadmium-binding moiety with properties in common with adult cadmiumthionein was identified in the livers of fetal rats at day 18 of gestation. Pregnant rats (approx. 200 g) were subcutaneously injected with 50 μg of radiolabeled cadmium in the form of 115mCdCl2 daily from days 11 through 15 of gestation. Maternal liver contained 14-18 μg Cd/g tissue; fetal liver contained 44-70 ng Cd/g tissue. A soluble (aqueous), heat stable, cadmium-binding molecule(s) was found which had an apparent molecular weight of approx. 10 000 in adult livers and 6000 in fetal livers by gel filtration chromatography. Both fetal and adult proteins absorbed maximally at 254 but not 280 nm. © 1979.

引用

页码：135 / 141

页数：7

共 13 条

[1]

BRENNER I, 1977, BR J NUTR, V38, P87

[2]

CHERIAN MG, 1974, BIOCHEM BIOPH RES CO, V61, P920

[3] TERATOGENIC EFFECTS OF CADMIUM IN RATS [J].