EFFECT OF NANOPARTICLES ON TRANSDERMAL DRUG DELIVERY

被引：36

作者：

CAPPEL, MJ ^{[1
]}

KREUTER, J ^{[1
]}

机构：

[1] UNIV FRANKFURT,INST PHARMAZEUT TECHNOL,GEORG VOIGT STR 16,W-6000 FRANKFURT,GERMANY

来源：

JOURNAL OF MICROENCAPSULATION | 1991年 / 8卷 / 03期

关键词：

D O I：

10.3109/02652049109069563

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The purpose of the present study was to assess by in vitro means the effect of poly (methylmethacrylate) nanoparticles and poly (butylcyanoacrylate) nanoparticles on transdermal drug delivery. Methanol and octanol were chosen as test permeants. In order to distinguish between thermodynamic effect and those due to biological consequences, two different membranes were employed, i.e., full thickness hairless mouse skin and silicone elastomer sheeting (175-mu-m). It is evident that poly (methylmethacrylate) nanoparticles and poly (butylcyanoacrylate) nanoparticles increase the permeability of methanol through hairless mouse skin by a factor of 1.2-2. The permeability of lipophilic octanol is either unaffected by nanoparticles or decreases as a function of nanoparticle concentration depending on the lipophilicity of the polymer material.

引用

页码：369 / 374

页数：6

共 12 条

[1]

Cappel M.J., Kreuter J., Effect of nonionic surfactants on transdermal drug delivery I: Polysorbates, International Journal of Pharmaceutics, 69, pp. 143-153, (1991)

[2]

Cappel M.J., Kreuter J., Effect of nonionic surfactants on transdermal drug delivery II: Poloxamer and poloxamine surfactants, International Journal of Pharmaceutics, 69, pp. 155-167, (1991)

[3]

Cappel M.J., Kreuter J., Effect of nonionic surfactants on transdermal drug delivery II: Poloxamer and poloxamine surfactants, International Journal of Pharmaceutics, (accepted for publication), (1990)

[4]

Douglas S.J., Illum L., Davis S.S., Kreuter J., Particle size and size distribution of poly(butyl-2-cyanoacrylate) nanoparticles, Journal of Colloid and Interface Science, 101, pp. 149-158, (1984)

[5]

Harmia T., Kreuter J., Speiser P., Boye T., Gurny R., Kubis A., Enhancement of the myotic response of rabbits with pilocarpine loaded polybutylcyanoacrylate nanoparticles, International Journal of Pharmaceutics, 33, pp. 187-193, (1986)

[6]

Kreuter J., Possibilities of using nanoparticles as carriers for drugs and vaccines, Journal of Microencapsulation, 5, pp. 115-127, (1988)

[7]

Kreuter J., Nanoparticles as bioadhesive ocular drug delivery systems, Bioadhesive Drug Delivery Systems, pp. 203-212, (1990)

[8]

Kreuter J., Speiser P.P., New adjuvants on a polymethylmethacrylate base, Infection and Immunity, 13, pp. 204-210, (1976)

[9]

Kreuter J., Speiser P.P., In vitro studies of poly(methylmethacrylate) adjuvants, Journal of Pharmaceutical Sciences, 65, pp. 1624-1627, (1976)

[10]

Kreuter J., Zehnder H.J., The use of <sup>60</sup>Co-γ-irradiation for the production of vaccines, Radiation Effects, 85, pp. 161-166, (1978)

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