DIFFERENTIAL EFFECT OF IMMUNOSYMPATHECTOMY ON THE EXPRESSION OF RAT ENTERIC NEUROTRANSMITTERS

被引：12

作者：

BELAI, A

ABERDEEN, J

BURNSTOCK, G

机构：

[1] UNIV LONDON UNIV COLL,DEPT ANAT & DEV BIOL,GOWER ST,LONDON WC1E 6BT,ENGLAND

[2] UNIV LONDON UNIV COLL,CTR NEUROSCI,LONDON WC1E 6BT,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1992年 / 139卷 / 02期

基金：

英国惠康基金;

关键词：

ENTERIC NERVE; CATECHOLAMINE; PEPTIDE; NERVE GROWTH FACTOR;

D O I：

10.1016/0304-3940(92)90541-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of immunosympathectomy on the pattern of distribution of catecholamine- and peptide-containing nerve fibres and neurones in the myenteric and submucous plexuses of rat ileum was investigated. There was an increase in vasoactive intestinal polypeptide (VIP)-, galanin (GAL)- and substance P-like immunoreactivity in the myenteric plexus of ileum from rats treated with nerve growth factor (NGF) antiserum compared with controls. A similar increase in immunoreactivity was observed in VIP-, GAL- and neuropeptide Y (NPY)-containing submucous neurones and nerve fibres. In contrast. the immunosympathectomy had no effect on the pattern of distribution of catecholamine-, calcitonin gene-related peptide (CGRP)- and NPY-containing nerve fibres in the myenteric plexus or on substance P- and CGRP-containing neurones and nerve fibres of the submucous plexus. The findings of the present study suggest that NGF may differentially regulate the expression of enteric neuropeptides at a postnatal stage of development.

引用

页码：157 / 160

页数：4

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