EFFECT OF LONG-CHAIN ALKYLAMINES ON ARACHIDONATE METABOLISM IN MACROPHAGES

被引：1

作者：

DIETER, P ^{[1
]}

FITZKE, E ^{[1
]}

机构：

[1] UNIV FREIBURG,INST BIOCHEM,W-7800 FREIBURG,GERMANY

来源：

BIOLOGICAL CHEMISTRY HOPPE-SEYLER | 1991年 / 372卷 / 10期

关键词：

ARACHIDONATE; INHIBITOR; MACROPHAGES; PHOSPHOLIPASE-A2; PROSTAGLANDINS;

D O I：

10.1515/bchm3.1991.372.2.943

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The two long-chain alkylamines RO 31-4493 and RO 31-4639 inhibit in a concentration-dependent manner the zymosan-induced release of arachidonic acid, the conversion of arachidonic acid into thromboxane, prostaglandin E2 and D2 and the uptake and incorporation of exogenously added arachidonate into membrane lipids of liver macrophages. The generation of superoxide and the formation of inositol phosphates is not influenced by both agents. These results suggest a rather specific interaction of RO 31-4493 and RO 31-4639 with enzymes involved in the cellular metabolism of arachidonic acid.

引用

页码：943 / 946

页数：4

共 19 条

[1] RECEPTOR-MEDIATED ACTIVATION OF PHOSPHOLIPASE-A2 AND ARACHIDONIC-ACID RELEASE IN SIGNAL TRANSDUCTION
AXELROD, J
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1990, 18 (04) : 503 - 507
[2] INHIBITION OF PHOSPHOLIPASE
BLACKWELL, GJ
FLOWER, RJ
[J]. BRITISH MEDICAL BULLETIN, 1983, 39 (03) : 260 - 264
[3] PHOSPHOLIPASE-A2 - FUNCTION AND PHARMACOLOGICAL REGULATION
CHANG, J
MUSSER, JH
MCGREGOR, H
[J]. BIOCHEMICAL PHARMACOLOGY, 1987, 36 (15) : 2429 - 2436
[4] INHIBITION OF PHOSPHOLIPASE-A2 BY SOME LONG-CHAIN ALKYLAMINES
DAVIS, PD
NIXON, JS
WILKINSON, SE
RUSSELL, MGN
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1988, 16 (05) : 816 - 817
[5] PHOSPHOLIPASE-A2 MECHANISM - INHIBITION AND ROLE IN ARACHIDONIC-ACID RELEASE
DENNIS, EA
[J]. DRUG DEVELOPMENT RESEARCH, 1987, 10 (04) : 205 - 220
[6] DIETER P, 1990, EICOSANOIDS, V3, P45
[7] PROSTAGLANDIN RELEASE BUT NOT SUPEROXIDE PRODUCTION BY RAT KUPFFER CELLS STIMULATED INVITRO DEPENDS ON NA+/H+ EXCHANGE
DIETER, P
SCHULZESPECKING, A
KARCK, U
DECKER, K
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 170 (1-2): : 201 - 206
[8] INDEPENDENT REGULATION OF THROMBOXANE AND PROSTAGLANDIN SYNTHESIS IN LIVER MACROPHAGES
DIETER, P
PETERS, T
SCHULZESPECKING, A
DECKER, K
[J]. BIOCHEMICAL PHARMACOLOGY, 1989, 38 (10) : 1577 - 1581
[9] 4-BROMOPHENACYL BROMIDE INHIBITS PROSTAGLANDIN-D2 SYNTHESIS FROM ARACHIDONIC-ACID RATHER THAN PHOSPHOLIPASE-A2 ACTIVITY IN LIVER MACROPHAGES
DIETER, P
SCHULZESPECKING, A
DECKER, K
[J]. BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1989, 370 (06): : 543 - 547
[10] CA-2+ REQUIREMENT OF PROSTANOID BUT NOT OF SUPEROXIDE PRODUCTION BY RAT KUPFFER CELLS
DIETER, P
SCHULZESPECKING, A
DECKER, K
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 177 (01): : 61 - 67

← 1 2 →