SYNTHESIS OF SUITABLY-PROTECTED PHOSPHORAMIDITES OF 2'-FLUORO-2'-DEOXYGUANOSINE AND 2'-AMINO-2'-DEOXYGUANOSINE FOR INCORPORATION INTO OLIGORIBONUCLEOTIDES

被引:20
作者
BENSELER, F [1 ]
WILLIAMS, DM [1 ]
ECKSTEIN, F [1 ]
机构
[1] MAX PLANCK INST EXPTL MED,CHEM ABT,HERMANN REIN STR 3,W-3400 GOTTINGEN,GERMANY
来源
NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 07期
关键词
D O I
10.1080/07328319208021177
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A novel synthesis of 2'-fluoro-2'-deoxyguanosine employing DAST as the fluorinating agent is presented. The preparation of its phosphoramidite as well as that of 2'-amino-2'-deoxyguanosine is also described.
引用
收藏
页码:1333 / 1351
页数:19
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