POTENTIAL ROLE OF IMIDAZOLINE (I-1) RECEPTORS IN MODULATING AQUEOUS-HUMOR DYNAMICS

被引：15

作者：

CAMPBELL, WR

POTTER, DE

机构：

[1] Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1994年 / 10卷 / 01期

关键词：

D O I：

10.1089/jop.1994.10.393

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

1) Moxonidine (MOX), injected icvt into the anterior lateral ventricle of NZW rabbits, induced bilateral, ocular hypotension ( > 7.0 mmHg) that persisted for two hrs. 2) Oxymetazoline (OXY), injected icvt into the anterior lateral ventricle of NZW rabbits, induced bilateral ocular hypotension ( > 7.0 mmHg) that peaked at two hrs. 3) Unilateral topical application of OXY induced maximal, bilateral ocular hypotension ( > 12 mmHg), at 3 hrs, in both the contralateral and ipsilateral eyes, that persisted more than 12 hrs. 4) The putative imidazoline (I-1) antagonist, efaroxan, injected icvt into the anterior lateral ventricle, - inhibited significantly the ocular hypotension produced by icvt MOX, icvt OXY, and unilateral topical OXY. 5) Imidazoline (I-1) receptors, located in the CNS, play a role in MOX- and OXY-induced ocular hypotension, as suggested by the ability of the putative imidazoline (I-1) receptor antagonist efaroxan, to inhibit icvt MOX-, icvt OXY- and topical OXY-induced ocular hypotension.

引用

页码：393 / 402

页数：10

共 25 条

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