CONCURRENT ACUTE MEGALOBLASTIC-ANEMIA AND PNEUMONITIS - A SEVERE SIDE-EFFECT OF LOW-DOSE METHOTREXATE THERAPY DURING RHEUMATOID-ARTHRITIS

被引：9

作者：

BOLLA, G

DISDIER, P

HARLE, JR

VERROT, D

WEILLER, PJ

机构：

[1] Service de Medecine Interne du Professeur P.J. WEILLER, Centre Hospitalo-Universitaire de la Timone, Marseille

来源：

CLINICAL RHEUMATOLOGY | 1993年 / 12卷 / 04期

关键词：

METHOTREXATE; TOXICITY; FOLIC ACID; RHEUMATOID ARTHRITIS;

D O I：

10.1007/BF02231787

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis. A combination of methotrexate suspension, folinic acid and corticosteroids led to recovery. The correlation between the haematologic and pneumologic toxicity is discussed.

引用

页码：535 / 537

页数：3

共 10 条

[1]

Scully C.J., Anderson C.J., Cannon G.W., Long-term methotrexate therapy for rheumatoid arthritis, Semin Arthritis Rheum, 20, pp. 317-331, (1991)

[2]

Weinblatt M.E., Fraser P., Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexate therapy, Arthritis Rheum, 32, pp. 1592-1596, (1989)

[3]

Clamon G.H., Feld R., Evans W.K., Weiner R.S., Kramer B.S., Lininge L.L., Gardner L.B., Wolfe E.C., Dewys W.D., Hoffman F.A., Serum folate and vitamin B 12 levels in patients with small lung cancer, Cancer, 53, pp. 306-310, (1984)

[4]

Ames B.N., Gold L.S., Endogenous mutagens and the causes of aging and cancer, Mutat Res, 250, pp. 3-16, (1991)

[5]

Stewart K.A., Mackenzie A.H., Clough J.D., Wilke W.S., Folate supplementation in methotrexate-treated rheumatoid arthritis, Semin Arthritis Rheum, 20, pp. 332-338, (1991)

[6]

Cohen O., Leibovici L., Wysenveck A.I., Carcinoma of the prostate presenting as interstital lung disease, Respiration, 51, pp. 158-160, (1987)

[7]

Segal P., Yaron M., Tartakowsky B., Methotrexate : Mechanism of action in rheumatoid arthritis, Semin Arthritis Rheum, 20, pp. 190-199, (1990)

[8]

Cook N.J., Caroll G.J., Successful reintroduction of methotrexate after pneumonitis in two patients with rheumatoid arthritis, Ann Rheum Dis, 51, pp. 272-274, (1992)

[9]

Morgan S.L., Bagott J.E., Vaughn W.H., The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis, Arthritis Rheum, 33, pp. 9-18, (1990)

[10]

Joyce D.A., Will R.K., Hoffman D.M., Laing B., Blackbourn S.J., Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid, Ann Rheum Dis, 50, pp. 913-914, (1991)

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