MITOCHONDRIAL TOXICITY OF ANTIVIRAL DRUGS

被引：615

作者：

LEWIS, W ^{[1
]}

DALAKAS, MC ^{[1
]}

机构：

[1] NINCDS, MED NEUROL BRANCH, BETHESDA, MD 20892 USA

来源：

NATURE MEDICINE | 1995年 / 1卷 / 05期

关键词：

D O I：

10.1038/nm0595-417

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long-term treatment with antiviral nucleoside analogue drugs, such as AZT, can give rise to delayed and at times severe mitochondrial toxicity. Although these toxic effects are manifest in many tissues, a common disease mechanism can explain the diverse clinical events. A better understanding of these disorders will shed light on genetic mitochondrial diseases and lead to the design of safer and more effective antiviral drugs.

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页码：417 / 422

页数：6

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