CLINICAL AND LABORATORY STUDIES OF NOSOCOMIAL STAPHYLOCOCCUS-AUREUS RESISTANT TO METHICILLIN AND AMINOGLYCOSIDES

被引：14

作者：

BOCK, BV ^{[1
]}

PASIECZNIK, K ^{[1
]}

MEYER, RD ^{[1
]}

机构：

[1] VET ADM WADSWORTH MED CTR, RES SERV, INFECT DIS SECT, LOS ANGELES, CA 90073 USA

来源：

INFECTION CONTROL & HOSPITAL EPIDEMIOLOGY | 1982年 / 3卷 / 03期

关键词：

D O I：

10.1017/S0195941700056149

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A methicillin/aminoglycosided-resistant strain of S. aureus (MARS) was likely introduced by transfer of a patient from another hospital. Over the next yr, 20 other patients were colonized or infected with MARS of the same phage type, although antibiograms varied. Affected patients usually had serious underlying disease and were in intensive care units. Vancomycin therapy was frequently delayed and MARS may have contributed to the death of some patients. The mode of spread was not definitively delineated, but 2 nurses were found to be colonized. Institution of isolation procedures was difficult, but the problem gradually waned. Susceptibility testing showed vancomycin to be the most active agent. Synergy studies showed no consistent effect of combining methicillin with an aminoglycoside. This experience illustrates the problem of MARS spread between hospitals and wards, the need for institution of effective control measures and consideration of early empiric use of vancomycin.

引用

页码：224 / 229

页数：6