REACTIVITY OF BIOLOGICALLY IMPORTANT REDUCED PYRIDINES .2. THE OXIDATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) - AN MNDO STUDY

被引:11
作者
BREWSTER, ME [1 ]
KAMINSKI, JJ [1 ]
BODOR, N [1 ]
机构
[1] UNIV FLORIDA, COLL PHARM, CTR DRUG DESIGN & DELIVERY, GAINESVILLE, FL 32610 USA
关键词
D O I
10.1021/ja00227a010
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:6337 / 6341
页数:5
相关论文
共 44 条
[1]   METABOLISM OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) IN MOUSE-LIVER PREPARATIONS [J].
BAKER, JK ;
BORNE, RF ;
DAVIS, WM ;
WATERS, IW .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (02) :484-490
[2]   FORMATION, STABILITY, AND PROTONATION OF DIHYDROPYRIDINES - MINDO-3 STUDY [J].
BODOR, N ;
PEARLMAN, R .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (16) :4946-4953
[3]   SITE-SPECIFIC, SUSTAINED-RELEASE OF DRUGS TO THE BRAIN [J].
BODOR, N ;
FARAG, HH ;
BREWSTER, ME .
SCIENCE, 1981, 214 (4527) :1370-1372
[4]  
Bodor N., 1983, PHARMACOL THERAPEUT, V19, P337
[5]   IMPROVED DELIVERY THROUGH BIOLOGICAL-MEMBRANES .32. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF BRAIN-TARGETED DELIVERY SYSTEMS FOR VARIOUS ESTRADIOL DERIVATIVES [J].
BREWSTER, ME ;
ESTES, KS ;
BODOR, N .
JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (01) :244-249
[6]  
BREWSTER ME, IN PRESS NEUROSCI LE
[7]   KINETICS OF THE REDUCTION OF C-9 SUBSTITUTED ACRIDINIUM CATIONS BY 1,4-DIHYDRONICOTINAMIDES [J].
BUNTING, JW ;
CHEW, VSF ;
CHU, G ;
FITZGERALD, NP ;
GUNASEKARA, A ;
OH, HTP .
BIOORGANIC CHEMISTRY, 1984, 12 (02) :141-157
[8]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[9]   MODELING THE PHASE-CHANGE IN CRYSTALLINE BIPHENYL BY USING A TEMPERATURE-DEPENDENT POTENTIAL [J].
BUSING, WR .
ACTA CRYSTALLOGRAPHICA SECTION A, 1983, 39 (MAY) :340-347
[10]   OXIDATION OF NADH INVOLVING RATE-LIMITING ONE-ELECTRON TRANSFER [J].
CARLSON, BW ;
MILLER, LL ;
NETA, P ;
GRODKOWSKI, J .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (23) :7233-7239