NUCLEATION PHENOMENA IN AMORPHOUS SUCROSE SYSTEMS

被引：38

作者：

VANSCOIK, KG

CARSTENSEN, JT

机构：

[1] Department 496, Abbott Laboratories, North Chicago, IL 60064

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 58卷 / 03期

关键词：

Amorphous state; Crystallization; Nucleation; Phase transition; Sucrose;

D O I：

10.1016/0378-5173(90)90194-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study investigated the phase transformation of amorphous to crystalline sucrose. Particular attention was paid to the nucleation phenomenon, and a method was developed to isolate nucleation kinetics from crystallization kinetics. Using this method and a simple mathematical model, various nucleation parameters could be determined. Additionally, the effects that additives, temperature, and relative humidity have on the inhibition or acceleration of nucleation were examined and are reported. © 1990.

引用

页码：185 / 196

页数：12

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