BICUCULLINE INDUCED SEIZURES IN INFANT RATS - ONTOGENY OF BEHAVIORAL AND ELECTROCORTICAL PHENOMENA

被引：43

作者：

BARAM, TZ ^{[1
]}

SNEAD, OC ^{[1
]}

机构：

[1] UNIV SO CALIF,DEPT NEUROL,LOS ANGELES,CA 90089

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1990年 / 57卷 / 02期

关键词：

BICUCULLINE; SEIZURE; ONTOGENY; RAT-GAMMA-AMINOBUTYRIC ACID; BRAIN DEVELOPMENT;

D O I：

10.1016/0165-3806(90)90055-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effects of bicuculline, a gamma-aminobutyric acid (GABA) antagonist, were investigated in 258 immature rats between the third and 22nd postnatal days. Behavioral and electrocorticographic events were correlated. Bicuculline induced both behavioral and electrographic seizures as early as the third postnatal day, an age when the CD50 for bicuculline was lowest, and therefore the sensitivity to it was the greatest. Bicuculline may thus be a suitable convulsant for epilepsy studies involving rats during the first postnatal week.

引用

页码：291 / 295

页数：5

共 26 条

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