INHIBITION OF THE BINDING OF HIV RGP120 TO CD4 BY DYES

被引：17

作者：

WEAVER, JL

PINE, PS

ANAND, R

BELL, S

ASZALOS, A

机构：

[1] US FDA, CDER, DIV RES & TESTING, HFD 471, 200 C ST SW, WASHINGTON, DC 20204 USA

[2] US FDA, RETROVIROL LAB, BETHESDA, MD 20014 USA

[3] US FDA, CFSAN, DIV COLORS & COSMET, WASHINGTON, DC 20204 USA

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1992年 / 3卷 / 03期

关键词：

D O I：

10.1177/095632029200300303

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have found that several dye compounds have the ability to inhibit the binding of HIV rgp120 to the Leu3a epitope of CD4 on PBL. One of these compounds, selected for further testing as the best candidate, can inhibit the growth of HIV in vitro. The tested dyes have varying degrees of specificity and efficacy in inhibiting the binding of rgp120. These results may point towards compounds that can be useful therapeutics against HIV.

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页码：147 / 151

页数：5

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