EFFECT OF SOME ANTIBIOTICS AND BIOCIDES ON PLASMID TRANSFER IN STAPHYLOCOCCUS-AUREUS

被引：35

作者：

ALMASAUDI, SB

DAY, MJ

RUSSELL, AD

机构：

[1] UNIV WALES COLL CARDIFF,COLL CARDIFF,WELSH SCH PHARM,POB 13,CARDIFF CF1 3XF,WALES

[2] UNIV WALES COLL CARDIFF,COLL CARDIFF,SCH PURE & APPL BIOL,CARDIFF CF1 3XF,WALES

来源：

JOURNAL OF APPLIED BACTERIOLOGY | 1991年 / 71卷 / 03期

关键词：

D O I：

10.1111/j.1365-2672.1991.tb04454.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The effects of some antibiotics and biocides on the conjugative transfer of the Staphylococcus aureus gentamicin resistance plasmid pWG613 were investigated. Gentamicin and vancomycin were found to stimulate plasmid transfer frequency by 10- to 20-fold whereas methicillin and three inhibitors of protein synthesis each reduced it by various degrees. Most significantly, mupirocin inhibited plasmid transfer frequency by more than 1000-fold. All the biocides tested (cationic agents, sodium dodecyl sulphate and an organomercurial) reduced plasmid transfer.

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页码：239 / 243

页数：5

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