PREVENTION OF GRAFT-VERSUS-HOST DISEASE FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION IN RATS USING FK506

被引:41
作者
MARKUS, PM
XIN, C
WEI, M
DEMETRIS, AJ
FUNG, JJ
STARZL, TE
机构
[1] UNIV PITTSBURGH,DEPT SURG,DIV TRANSPLANTAT SURG,3601 5TH AVE,PITTSBURGH,PA 15213
[2] UNIV PITTSBURGH,CTR HLTH,DEPT PATHOL,PITTSBURGH,PA 15213
关键词
D O I
10.1097/00007890-199110000-00002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
FK506 and cyclosporine were used for the prevention of acute graft-versus-host disease. Acute GVHD was induced in Lewis rats by total-body irradiation and subsequent reconstitution with allogeneic (ACI) bone marrow and spleen cells (BMTx). GVHD was assessed by both clinical and histologic parameters during the experiment duration of 60 days, and longer for selected animals. All untreated BM recipients died within 26 days from severe acute GVHD. GVHD was prevented with CsA during the period of immunosuppressive therapy, but it appeared within a few days afterward. FK506-treated BM recipients were also protected, but they had a markedly prolonged GVHD-free period after therapy was discontinued. Most such animals eventually developed GVHD but with notable exceptions. Maintenance therapy with doses of FK506 as low as 0.1 mg/kg every other day (1/20 of daily induction dose) was infallible insurance against delayed GVHD. The relevance of these findings to GVHD caused by lymphoid-containing solid organs such as the intestine was discussed.
引用
收藏
页码:590 / 594
页数:5
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