AMPLIFICATION OF CHROMOSOME SUBREGION 12P11.2-P12.1 IN A METASTASIS OF AN I(12P)-NEGATIVE SEMINOMA - RELATIONSHIP TO TUMOR PROGRESSION

被引：66

作者：

SUIJKERBUIJK, RF

SINKE, RJ

WEGHUIS, DEMO

ROQUE, L

FORUS, A

STELLINK, F

SIEPMAN, A

VANDEKAA, C

SOARES, J

VANKESSEL, AG

机构：

[1] UNIV NIJMEGEN HOSP, DEPT HUMAN GENET, 6500 HB NIJMEGEN, NETHERLANDS

[2] INST PORTUGUES ONCOL FRANCISCO GENTIL, PATOL EXPTL LAB, LISBON, PORTUGAL

[3] NORWEGIAN RADIUM HOSP, DEPT TUMOR BIOL, OSLO, NORWAY

[4] UNIV NIJMEGEN HOSP, DEPT PATHOL, NIJMEGEN, NETHERLANDS

来源：

CANCER GENETICS AND CYTOGENETICS | 1994年 / 78卷 / 02期

关键词：

D O I：

10.1016/0165-4608(94)90082-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis of a metastasis of a human testicular germ cell tumor (seminoma) revealed multiple numerical and structural anomalies, including an abnormally banding region (ABR) present on the short arm of one of the chromosome 12 homologs. Fluorescence in situ- and comparative genomic hybridization experiments revealed that the ABR results from the amplification of 12p11.2-p12.1 derived sequences. We speculate that this particular region may harbor gene(s) relevant for testicular germ cell tumor progression.

引用

页码：145 / 152

页数：8

共 33 条

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