PROGRAMMED CELL-DEATH (APOPTOSIS) IN HUMAN MONOCYTES INFECTED BY INFLUENZA-A VIRUS

被引:141
作者
FESQ, H [1 ]
BACHER, M [1 ]
NAIN, M [1 ]
GEMSA, D [1 ]
机构
[1] PICOWER INST,MANHASSET,NY
关键词
D O I
10.1016/S0171-2985(11)80292-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although infection of monocytes by influenza A virus primes for a high cytokine release, it also leads to cell death within 20-30 hours. In this brief report, we demonstrate that influenza A virus-induced monocyte killing was due to programmed cell death (apoptosis) and not to necrosis. Morphologically, chromatin condensation and margination occurred and biochemically, an apoptosis-specific internucleosomal DNA fragmentation into multimers of 180 bp (<<DNA ladder>>) was found. Induction of apoptosis and not necrosis in influenza A virus-infected monocytes may serve three purposes: 1. Virus replication is limited, 2. a priming for a high cytokine response is initiated and 3. damaging and inflammation-inducing lysosomal enzymes are held back from monocytes undergoing controlled cell death.
引用
收藏
页码:175 / 182
页数:8
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