AIRWAYS REMODELING IN ASTHMA - NO DOUBT, NO MORE

被引：64

作者：

BOUSQUET, J

VIGNOLA, AM

CHANEZ, P

CAMPBELL, AM

BONSIGNORE, G

MICHEL, FB

机构：

[1] CHU MONTPELLIER,MALAD RESP CLIN,MONTPELLIER,FRANCE

[2] CHU MONTPELLIER,INSERM,CJF 9210,MONTPELLIER,FRANCE

[3] IST FISIOPATOL RESP,PALERMO,ITALY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

ASTHMA; AIRWAY REMODELING; TGF-BETA; EGF; AIRWAY INFLAMMATION;

D O I：

10.1159/000236980

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma is a chronic inflammatory disease of the airways invariably associated with healing. Remodelling of the airways can be demonstrated by the activation of airways macrophages, the release of growth factors and fibrogenic cytokines, the activation of fibroblasts and myofibroblast, elastolysis and elastosynthesis, collagen deposition, increased synthesis and release of extracellular matrix components, and an increased mass of smooth muscle and mucous glands. However, the control of remodelling is still poorly understood.

引用

页码：211 / 214

页数：4

共 18 条

[1] INDIRECT EVIDENCE OF BRONCHIAL INFLAMMATION ASSESSED BY TITRATION OF INFLAMMATORY MEDIATORS IN BAL FLUID OF PATIENTS WITH ASTHMA
BOUSQUET, J
CHANEZ, P
LACOSTE, JY
ENANDER, I
VENGE, P
PETERSON, C
AHLSTEDT, S
MICHEL, FB
GODARD, P
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1991, 88 (04) : 649 - 660
[2] ASTHMA - A DISEASE REMODELING THE AIRWAYS
BOUSQUET, J
CHANEZ, P
LACOSTE, JY
WHITE, R
VIC, P
GODARD, P
MICHEL, FB
[J]. ALLERGY, 1992, 47 (01) : 3 - 11
[3] MYOFIBROBLASTS AND SUBEPITHELIAL FIBROSIS IN BRONCHIAL-ASTHMA
BREWSTER, CEP
HOWARTH, PH
DJUKANOVIC, R
WILSON, J
HOLGATE, ST
ROCHE, WR
[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1990, 3 (05) : 507 - 511
[4] THE STRUCTURE OF LARGE AND SMALL AIRWAYS IN NONFATAL AND FATAL ASTHMA
CARROLL, N
ELLIOT, J
MORTON, A
JAMES, A
[J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (02): : 405 - 410
[5] A COMPARISON OF QUANTITATIVE ANATOMY OF BRONCHI IN NORMAL SUBJECTS IN STATUS ASTHMATICUS IN CHRONIC BRONCHITIS AND IN EMPHYSEMA
DUNNILL, MS
MASSARELLA, GR
ANDERSON, JA
[J]. THORAX, 1969, 24 (02) : 176 - +
[6] CELLULAR HYPERTROPHY AND HYPERPLASIA OF AIRWAY SMOOTH MUSCLES UNDERLYING BRONCHIAL-ASTHMA - A 3-D MORPHOMETRIC STUDY
EBINA, M
TAKAHASHI, T
CHIBA, T
MOTOMIYA, M
[J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (03): : 720 - 726
[7] CYTOKINES .4. CYTOKINES AND PULMONARY FIBROSIS
GAULDIE, J
JORDANA, M
COX, G
[J]. THORAX, 1993, 48 (09) : 931 - 935
[8] FUNCTIONAL ASSESSMENT OF ALVEOLAR MACROPHAGES - COMPARISON OF CELLS FROM ASTHMATICS AND NORMAL SUBJECTS
GODARD, P
CHAINTREUIL, J
DAMON, M
COUPE, M
FLANDRE, O
DEPAULET, AC
MICHEL, FB
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1982, 70 (02) : 88 - 93
[9] INCREASED SECRETION OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-6 BY ALVEOLAR MACROPHAGES CONSECUTIVE TO THE DEVELOPMENT OF THE LATE ASTHMATIC REACTION
GOSSET, P
TSICOPOULOS, A
WALLAERT, B
VANNIMENUS, C
JOSEPH, M
TONNEL, AB
CAPRON, A
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1991, 88 (04) : 561 - 571
[10] EXAGGERATED SPONTANEOUS RELEASE OF PLATELET-DERIVED GROWTH-FACTOR BY ALVEOLAR MACROPHAGES FROM PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS
MARTINET, Y
ROM, WN
GROTENDORST, GR
MARTIN, GR
CRYSTAL, RG
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) : 202 - 209

← 1 2 →