STEREOSELECTIVE DEUTERATION OF A BRIDGEHEAD POLYCYCLIC 2-NITRO ALCOHOL THROUGH A RETRO-HENRY REACTION

被引:5
作者
CAMPS, P
MUNOZTORRERO, D
MUNOZTORRERO, V
机构
[1] Laboratori de Química Farmacèutica, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Av. Diagonal s/n
关键词
D O I
10.1016/0040-4020(95)00296-K
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Reaction of nitro alcohol 2a with the stoichiometric amount of NaOH in water or D2O gave ketonitronate 3a or 3c, respectively. In CD3OD or CH3OH solution It room temperature, 3a and 3c gave cleanly the dideuterated derivatives 3b and 3d, respectively. Treatment of 3a-d with acetic acid gave the corresponding polycyclic nitro alcohols 2a-d.
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收藏
页码:6587 / 6590
页数:4
相关论文
共 5 条
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