EFFECTS IN-VITRO OF SULFATED POLYSACCHARIDE FROM SCHIZYMENIA-DUBYI (RHODOPHYTA, GIGARTINALES) ON A NON-SMALL-CELL BRONCHOPULMONARY CARCINOMA LINE (NSCLC-N6)

被引：24

作者：

BOURGOUGNON, N

ROUSSAKIS, C

KORNPROBST, JM

LAHAYE, M

机构：

[1] FAC PHARM NANTES,ISOMER,GRP SMAB,F-44035 NANTES 01,FRANCE

[2] INRA,BIOCHIM & TECHNOL GLUCIDES LAB,F-44026 NANTES 03,FRANCE

来源：

CANCER LETTERS | 1994年 / 85卷 / 01期

关键词：

SULFATED POLYSACCHARIDES; SCHIZYMENIA DUBYI; TERMINAL DIFFERENTIATION; BRONCHOPULMONARY CARCINOMA (NSCLC);

D O I：

10.1016/0304-3835(94)90243-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An unusual sulfated heteropolysaccharide containing uronic acids, previously isolated from the red alga Schizymenia dubyi, was studied in vitro for its effect on asynchronous cells of a human non-small-cell-bronchopulmonary carcinoma line (NSCLC-N6). Cell growth appeared to be inhibited in the G(1) phase of the cell cycle, and kinetic studies in pretreated cells showed that this growth arrest was irreversible. These events are related to a terminal maturation induction.

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页码：87 / 92

页数：6

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